When you’ve got a really bad headache or some general aches and pains, do you ever hesitate at your medicine cabinet, wondering which pill you should reach for? I’ve definitely been unsure at times whether it’s better to take the ibuprofen or the acetaminophen. And it turns out, there is definitely reason to take pause and weight the pros and cons, depending on your ailment, your age, and several other factors. The Wall Street Journal thankfully sheds some light on this topic, making this decision an easier one whenever pain arises.

Still not sure? Take a look at this handy chart to help you decide which pain killer is right for you and your current ailment.