What Ingredients are Used in Compounded Pain Creams?

Compounding pain creams work to reduce the pain by compounding specialized specifications. Pharmaceutical companies use all FDA approved ingredients in making these creams. Compounded creams blocks the pain at the appropriate nerve source when applied directly on the affected dermatome. Researches on compounding has been still going on for years to allow more pharmacists in preparing compounded creams easily to meet patient requirements. Pharmacists are restricted to use the ingredients that are prescribed by the physician who analyzes patient need. Considering FDA reports till 1960, 80% of the physician’s prescription to the companies are compounded. This shows the domination of compounded drugs over the manufacture and supply of the non-compounded drugs. Now, considering the daily reports, 1% of the physician’s prescription to the companies are compounded.

Different patients have different physical sizes, allergies, pain tolerance capacity and symptoms, medications available at the counters do not match with every patient while compounding do. According to recent compounding development research, various types of skin have different capacity in absorbing the medicine when rubbed on it. Variation in medicine absorption depends on several factors. So pharmacists and physician started working on such ingredients that absorbs the medicine quickly when it rubbed on the skin irrespective of the skin types.

The following is the list of agents which consists of ingredients used in compounded pain cream
manufacturing:-

• Muscle Relaxants
• Pain Blockers
• Vasodilators
• Non-steroidal Antiinflammatories
• Anesthetics
• Nerve Agents
• Other pain medications

Muscle Relaxants :

These are used to relax the muscles through which pain reduces. When muscle relaxants are mixed in oral medication causes drowsiness, fatigue and other side effects, but this cannot be seen in topical use. Muscle relaxants also help in controlling muscle spasms and muscle tightness. Cyclobenzaprine, Baclofen, Guaifenasin ingredients used as muscle relaxants in compounded pain creams.

Pain Blockers :

These are the agents that relieves the pain without affecting the skin or nerve or muscle sensation. Pain reduction is done with obstruction of pain signals from the brain. Ketamine is the only ingredient used as a pain blocker in compounded pain cream manufacture.

Vasodilators :

Lowers high blood pressure and increases blood flow. Good blood flow increases the medicine reach to the affected tissue. Nifedipine, Verapamil ingredients used as vasodilators.

Non-steroidal Antiinflammatories :

NSAIDS reduces the hormone proportionate in the blood that causes inflammation. Ketoprofen, Piroxicam, Ibuprofen ingredients used as Non-steroidal Antiinflammatories.

Anesthetics :

Anesthetics reduce the pain, Lidocaine, Prilocaine is the two ingredients used as Anesthetics. Lidocaine causes tingling and numbness on the applied site.

Nerve Agents :

These treats the nerves that are responsible for pain, these ingredients play important role in chronic pains. Nerve agents even react with spinal nerves and reduces pain. Amitriptyline, Gabapentin ingredients used as nerve agents.

Other Pain Medications :

Menthol, Capsaicin, the other pain medication ingredients. Capsaicin deplete the chemical in nerve cells which are responsible for sending pain signals. Menthol temporarily eliminates the ability to feel the pain by producing a hot or cold sensation.

Each ingredient type has more than one ingredient that can be used in compounded pain cream manufacturing except for pain blocker agent where there is only one ingredient. Depending on the doctor prescription ingredients are chosen and compounded by the pharmacists.

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